Bio-Remodelling Treatment to Regenerate Volume Loss and Skin Sagging

As we age, not only does our skin quality diminish, but we also lose the supportive volume in deeper layers – especially fat and collagen in the cheeks, temples, and other areas. This volume loss contributes to sagging, hollows, and the formation of folds. Our bio-remodelling treatment for volume restoration is a cutting-edge injectable procedure that works by stimulating your skin’s own collagen production to gradually restore lost volume and improve firmness. This is often referred to as a collagen biostimulator treatment. Instead of instantly filling areas like a traditional filler, we inject a specialized solution (containing substances such as poly-L-lactic acid microspheres, for example) that triggers the body to produce new collagen over time. The results emerge gradually but can be long-lasting, giving a very natural rejuvenation.

One of the known products in this category (we avoid using brand names due to regulations) has been used for years to treat facial lipoatrophy and volume loss. It’s an FDA-approved approach to address shallow to deep nasolabial folds, hollow cheeks, and overall facial contour deficiencies by harnessing your body’s regenerative capacity. Essentially, we’re helping your tissue rebuild itself. This is ideal for those who want a subtle, overall volumizing and tightening effect without the upkeep of frequent filler appointments.

Treatment Overview

Treatment with a biostimulatory injectable is typically done as a series of sessions. During each session, the product is mixed properly (these often come as vials of powder that we reconstitute with sterile water) and injected into targeted areas of volume loss. Common areas include the midface (to lift cheeks), the hollows in front of your ears or in the temples, the jawline (to reduce jowling), and sometimes fine lines on the cheeks or chin region. The injection technique often involves tunneling threads or a cross-hatch pattern with a needle or cannula to distribute the product evenly in the tissue.

You will feel some injection pricks; a local anesthetic in the mix or topical numbing makes it comfortable. After injection, we perform a thorough massage of the treated areas. This is a crucial step to ensure the product is evenly spread and to reduce the chance of small nodules forming. You’ll actually be instructed to do a specific massage routine at home too (more on that in aftercare). Each session takes about 30-40 minutes. Because we are not placing a large volume of gel (as with fillers), you won’t walk out with a dramatically different look that day – aside from possibly some swelling. The magic happens over the weeks following as your body produces new collagen where the product was placed.

Pre- and Post-Treatment Care

Preparation: Ensure you’re not on any medications that could contraindicate injections (we’ll go over your health history). Similar to other injections, avoiding blood thinners and supplements like fish oil, vitamin E, etc., for a week prior can help reduce bruising. It’s good to come well-hydrated. There’s no need for any pre-skin treatment, but do avoid any aggressive skin procedures (like lasers or deep peels) in the week leading up to your session.

Aftercare: A unique aspect of collagen-stimulating injectables is the massage requirement. We’ll teach you the “5-5-5” rule: massage the treated areas for 5 minutes, 5 times a day, for 5 days. This massage should be gentle but firm enough to feel the area under the skin smoothing out. You can use a moisturizer or arnica cream to give some slip while massaging. This step is important to distribute the product evenly and help prevent the formation of any small bumps under the skin. Don’t worry – the product is designed to be moved and spread. Aside from massage, the general aftercare is like other injectables: no strenuous exercise or excessive heat for 24 hours, and avoid facials or facial massage (aside from your specific routine) for a week or two. You might feel some mild soreness or see slight swelling in injected areas; this usually resolves in a few days. Bruising can occur, so arnica and concealer are your friends if so. Because the results are gradual, we’ll space sessions roughly 4-6 weeks apart. Typically 2 to 3 sessions are recommended for an optimal course. Patience is key, but the payoff is worth it.

Frequently Asked Questions

When will I see results?
This treatment is for the patient who is in it for the long game. You won’t see a dramatic change immediately – in fact, any fullness you see right after injection is mostly from slight swelling or the water used to dilute the product, and that subsides in a day or two. The real results start to show around 4-6 weeks later as your new collagen forms. Each session builds on the last. After the final session of your series, the collagen synthesis will continue for a couple of months. Many patients notice subtle improvements after the first session (skin feels firmer, makeup sits better), more noticeable changes after the second, and significant improvement after the third if one is done. It’s gradual enough that people will just think you’re looking refreshed, not suspecting you did a procedure. Full results are typically evaluated about 2-3 months after the last session.

How long do the effects last?
One of the advantages of collagen-stimulating treatments is their longevity. Because we are inducing your own collagen, the results can last 2 years or more. Studies and clinical experience have shown that the changes stick around as the new collagen matrix remains. Of course, you will continue to age, so nothing is permanent, but many patients enjoy a couple of years of benefit before considering a touch-up series. Some choose to do a single maintenance session about a year after their initial treatments just to prompt a bit more collagen and keep things up. It really comes down to the individual – we’ll monitor your results with you and make personalized recommendations.

Is it safe and what are the side effects?
Collagen biostimulators have an excellent safety profile, but they do require proper technique. Safety notes: If you’re very thin-skinned or have certain medical conditions, we’ll evaluate if this is the right treatment for you. Common side effects are similar to other injections: temporary redness, swelling, bruising, and tenderness at injection sites. There is a particular risk of forming small subcutaneous nodules or bumps if the product isn’t distributed properly or if you don’t massage as directed. These nodules are usually not visible and can only be felt, and often they resolve over time or with additional massage. Proper injection technique (diluting the product correctly and placing it in the right tissue plane) plus the post-treatment massage regimen greatly minimize this risk:contentReference[oaicite:21]{index=21}. Infection is extremely rare but a theoretical risk anytime a needle goes in – we take all antiseptic precautions. Allergic reaction to the material (like poly-L-lactic acid) is exceedingly rare since it’s biocompatible and eventually metabolized to harmless substances (water and CO₂). Overall, millions of these treatments have been done worldwide, and they are considered very safe when patient selection and aftercare are appropriate.

Can it be combined with other treatments?
Absolutely, and in many cases, a combination approach yields the best overall rejuvenation. Since the volume-building effect is gradual, some patients also get a few fillers in specific areas for instant results while waiting for collagen to kick in. It’s safe to have HA fillers in some spots and collagen stimulator in others – we would usually do them in separate appointments and plan accordingly. Neurotoxin injections (e.g., for forehead lines) work well alongside this, as they address wrinkles from muscle activity while the biostimulator addresses volume and skin thickness. We often do neuromodulators 1-2 weeks before or after a biostimulator session. Other skin treatments like microneedling, PRF, or laser can complement the collagen stimulation as well; we just space them out so as not to interfere with each other’s healing processes. During your personalized plan discussion, we’ll map out any combination therapy timing. Our goal is to layer treatments in a safe and effective sequence to maximize benefits.

Who is the ideal candidate for this treatment?
Ideal candidates are those with mild to moderate volume loss or skin laxity who desire a natural improvement and are patient enough to wait for results. If you have generalized hollowing of the cheeks or temples, early jowls, or a sort of overall “deflated” look in the face, this can work wonders by gradually re-inflating and firming. It’s also great for people who want longevity and don’t want frequent top-ups as required by regular fillers. On the other hand, if you have very deep set wrinkles or are looking for an overnight transformation, you might be better served with fillers or even surgical options – or a combination. We will give an honest assessment. This treatment is also popular among those who have done fillers and want to step down to something more subtle, or those who have never done cosmetic injectables and prefer a “soft start” that builds up gently. It’s not typically used in very young patients, since they usually don’t need it; most are mid-30s and up. We’ll evaluate factors like your skin thickness and elasticity to make sure this is a good fit.